The CDX2 (Clone CDX2/1690) Mouse Monoclonal Antibody is a highly specific and sensitive tool for detecting CDX2, a nuclear transcription factor expressed in the intestinal epithelium. CDX2 plays a crucial role in the regulation of proliferation and differentiation of intestinal epithelial cells and is a well-established marker of gastrointestinal (GI) origin tumors, especially colorectal adenocarcinomas. This antibody provides strong nuclear staining in normal and neoplastic intestinal epithelial cells and is optimized for immunohistochemistry on formalin-fixed, paraffin-embedded (FFPE) tissues.
Mouse
Recombinant human CDX2 protein fragment (aa150-249) (exact sequence is proprietary)
CDX2/1690
IgG2a, kappa
Human. Others not known.
HT29 cells or Colon Carcinoma.
Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein.
Nuclear