CEACAM5 ANTIBODY (Rabbit Monoclonal)
CLONE- GR370
Gene Bio Solution CEACAM5 Antibody. CEACAM5 Antibody (Rabbit Monoclonal) – High-Specificity Marker for Epithelial Tumors and Colorectal Cancer Diagnostics
The CEACAM5 Antibody (Rabbit Monoclonal) is a highly specific antibody designed for the detection of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5), also known as CEA (Carcinoembryonic Antigen). CEACAM5 is a cell surface glycoprotein extensively expressed in various epithelial tissues and is prominently overexpressed in many carcinomas, particularly colorectal, gastric, pancreatic, lung, and breast cancers.
This rabbit monoclonal antibody provides strong membranous and cytoplasmic immunostaining with excellent sensitivity and minimal background, making it an indispensable tool in immunohistochemistry (IHC) for both clinical diagnostics and cancer research. CEACAM5 is widely used as a tumor marker for identifying primary and metastatic adenocarcinomas, aiding in the differential diagnosis of gastrointestinal and other epithelial malignancies.
Applications and Clinical Importance:
Colorectal Cancer Detection: CEACAM5 is a key marker for colorectal adenocarcinomas, facilitating tumor identification and classification.
Tumor Origin Determination: Useful in distinguishing gastrointestinal tract cancers from other epithelial tumors.
Metastatic Carcinoma Workup: Helps pathologists confirm the origin of metastatic tumors with unknown primary sites.
Other Cancers: Detects CEACAM5 expression in gastric, pancreatic, lung, and breast carcinomas.
Research Applications: Supports studies on tumor progression, cell adhesion, metastasis, and epithelial biology.
Host Species: Rabbit
Antibody Type: Monoclonal IgG
Target: CEACAM5 / CEA glycoprotein
Reactivity: Human (validated)
Subcellular Localization: Membranous and cytoplasmic staining in tumor cells
Applications:
Immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues
Immunocytochemistry (ICC) with protocol optimization
