The CFTR (Clone CFTR/1643) Mouse Monoclonal Antibody is a highly specific reagent designed for the detection of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein in formalin-fixed, paraffin-embedded tissues and cell lysates. CFTR is a cAMP-regulated chloride channel that plays a crucial role in epithelial ion and fluid transport. Mutations in the CFTR gene are the underlying cause of Cystic Fibrosis (CF). This antibody demonstrates clear apical membrane staining in tissues with high CFTR expression and is suitable for cystic fibrosis research, ion transport studies, and cancer investigations.
Mouse
Recombinant human CFTR fragment (aa258-385) (exact sequence is proprietary).
CFTR/1643
IgG2b
Reacts with human. Others not known.
MOLT-4 cells. Pancreas, Kidney or Placenta.
Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR).
Cell Surface and Cytoplasmic.