The CFTR (Clone CFTR/1785) Mouse Monoclonal Antibody is developed for the specific and sensitive detection of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), a membrane-associated chloride channel protein. CFTR plays a central role in epithelial ion and fluid transport, and mutations in its gene are the primary cause of Cystic Fibrosis (CF). This clone provides robust apical membrane and cytoplasmic staining in epithelial tissues and is suitable for both immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded samples and Western blot applications. It is an excellent reagent for cystic fibrosis research, drug efficacy studies, and tumor profiling where CFTR expression is relevant.
Mouse
Recombinant human CFTR fragment (aa258-385) (exact sequence is proprietary).
CFTR/1785
IgG2b
Reacts with human. Others not known.
MOLT-4 cells. Pancreas, Kidney or Placenta.
Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR).
Cell Surface and Cytoplasmic.