The CFTR (Clone SPM176) Mouse Monoclonal Antibody is designed for the detection of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), a crucial chloride ion channel protein. CFTR is expressed primarily in epithelial cells and plays a vital role in fluid homeostasis and mucosal surface hydration across various organ systems. This antibody demonstrates strong apical membrane and cytoplasmic staining in normal epithelial tissues and provides consistent and specific results in immunohistochemistry (FFPE), Western blotting, and immunofluorescence applications. It is especially useful for research into cystic fibrosis pathophysiology, CFTR-targeted therapies, and epithelial biology.
Mouse
Recombinant human full-length CFTR.
SPM176
IgG2a
Reacts with human and mouse. Others not known.
MOLT-4 cells. Pancreas, Kidney or Placenta.
Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR).
Cell Surface and Cytoplasmic.