The CFTR (Clone CFTR/1341) Mouse Monoclonal Antibody is a highly specific and sensitive reagent for the detection of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), a chloride channel protein crucial for fluid and electrolyte balance across epithelial surfaces. Mutations in the CFTR gene result in Cystic Fibrosis (CF), a life-threatening autosomal recessive disorder that primarily affects the lungs and digestive system. This antibody is optimized for immunohistochemical detection of CFTR in formalin-fixed, paraffin-embedded tissues and is also suitable for Western blotting. It exhibits distinct apical membrane staining in epithelial cells of normal and neoplastic tissues where CFTR is expressed.
Mouse
Recombinant human full-length CFTR.
CFTR/1341
IgG1
Human. Others not known.
MOLT-4 cells. Pancreas, Kidney or Placenta.
Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR).
Cell surface and Cytoplasmic.