Chromogranin A (CHGA) (Neuroendocrine Marker); Clone PHE5 (Concentrate) is a well-characterized monoclonal antibody designed to detect Chromogranin A, a major glycoprotein stored in the secretory granules of neuroendocrine cells. Clone PHE5 demonstrates strong and specific cytoplasmic staining in formalin-fixed, paraffin-embedded (FFPE) tissue sections, making it a reliable and widely used marker in the identification of neuroendocrine differentiation. Chromogranin A is commonly expressed in a broad range of neuroendocrine tumors, including carcinoids, pancreatic neuroendocrine tumors, pheochromocytomas, paragangliomas, and small cell carcinomas. Clone PHE5 is particularly useful in the differential diagnosis of tumors with suspected neuroendocrine origin and can aid in distinguishing these from non-neuroendocrine malignancies. Supplied in a concentrated format, this antibody allows for flexible protocol optimization to suit various immunohistochemical workflows. Its high specificity and sensitivity make Clone PHE5 a dependable tool for both clinical diagnostics and neuroendocrine tumor research.
Mouse
Human pheochromocytoma
PHE5
IgG1, kappa
Human, Monkey. Does not react with Mouse and Rat. Others not known.
PC12 cells. Adrenal gland, bowel, thyroid, pancreas, or pheochromocytoma.
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets.
Finely granular cytoplasmic