Chromogranin A (CHGA) (Neuroendocrine Marker); Clone SPM553 (Concentrate) is a monoclonal antibody specifically designed to detect Chromogranin A, a key secretory protein localized within the dense-core granules of neuroendocrine cells. Clone SPM553 demonstrates strong, specific cytoplasmic staining in formalin-fixed, paraffin-embedded (FFPE) tissue sections, making it a valuable tool for identifying neuroendocrine differentiation in both normal tissues and a wide variety of tumors. Chromogranin A is a widely recognized marker for neuroendocrine neoplasms such as carcinoids, pancreatic neuroendocrine tumors, pheochromocytomas, and small cell carcinomas. Clone SPM553 is especially useful in diagnostic pathology to confirm neuroendocrine origin and to assist in tumor classification. Supplied in a concentrated format, this antibody offers flexibility for protocol optimization and consistent performance across a range of applications. Its high sensitivity and specificity make Clone SPM553 an essential reagent for both clinical diagnostics and research involving neuroendocrine tissues and tumors.
Mouse
Recombinant human Chromogranin A protein
SPM553
IgG1, kappa
Human. Others not known.
PC12 cells. Adrenal gland, bowel, thyroid, pancreas, or pheochromocytoma.
R ecognizes the Chromogranin A protein.
Finely granular cytoplasmic.