CK14 (Cytokeratin-14) Rabbit Monoclonal Antibody is a highly specific and sensitive reagent engineered to detect Cytokeratin 14 (KRT14), an essential intermediate filament protein predominantly expressed in the basal layer of stratified squamous epithelia. CK14 plays a key role in maintaining epithelial integrity and cellular structure, making it a valuable marker in both diagnostic immunohistochemistry (IHC) and epithelial biology research. This antibody is widely validated for use on formalin-fixed, paraffin-embedded (FFPE) tissue sections, providing clear, strong cytoplasmic staining with minimal background interference. It is instrumental in identifying basal epithelial cells, especially in tissues such as the skin, esophagus, oral mucosa, cervix, and tonsils, and is extensively used in detecting epithelial-derived malignancies. CK14 expression is highly indicative of basal-like differentiation and is commonly overexpressed in a range of tumor types, including squamous cell carcinoma, basal cell carcinoma, triple-negative and basal-like breast cancers, and head and neck squamous neoplasms. The recombinant rabbit monoclonal format ensures batch-to-batch consistency, enhanced affinity, and high specificity, making it a reliable choice for pathologists and researchers seeking reproducible results in both routine and advanced IHC assays. This antibody is also used in differential diagnosis to distinguish basal-type breast carcinomas from luminal subtypes and to confirm squamous differentiation in undifferentiated tumors. Its compatibility with a broad range of detection systems and antigen retrieval methods, such as heat-induced epitope retrieval (HIER) using citrate or EDTA buffers, makes it highly adaptable across different laboratory workflows. Furthermore, CK14 serves as a useful marker in stem cell research, wound healing studies, and tissue regeneration models, due to its restricted expression in basal progenitor cell populations.
GRM328
GRM328 reacts to human Cytokeratin-14. It may also react to mouse or rat Cytokeratin-14, as predicted by immunogen homology.
A peptide corresponding to C-terminus of human Cytokeratin-14
Immunohistochemistry (IHC) Western Blot (WB)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
