The CK8 & CK18 Antibody Cocktail (Clones B22.1 & B23.1) is a high-performance mouse monoclonal antibody mix designed for the immunohistochemical detection of Cytokeratin 8 (CK8) and Cytokeratin 18 (CK18) — two intermediate filament proteins expressed in simple epithelial tissues and a wide range of epithelial-derived tumors. This dual-antibody cocktail provides reliable and consistent cytoplasmic staining for both markers in formalin-fixed, paraffin-embedded (FFPE) tissue sections. Cytokeratins 8 and 18 are often co-expressed in glandular epithelial cells and are overexpressed in many carcinomas, including hepatocellular carcinoma, colorectal cancer, pancreatic cancer, lung adenocarcinoma, and prostate cancer. This makes the CK8/18 antibody cocktail a powerful tool for tumor identification, classification, and differentiation, particularly in IHC panels where simple epithelial differentiation must be confirmed. The B22.1 and B23.1 clones are specifically optimized to detect CK8 and CK18 with high sensitivity and minimal background staining. The antibody cocktail is validated for use on both manual and automated IHC platforms, and is available in both concentrated and ready-to-use formats, ensuring flexibility for various laboratory needs. Key Features: Clones: B22.1 (CK8) & B23.1 (CK18) Host Species: Mouse Monoclonal Target Proteins: Cytokeratin 8 and Cytokeratin 18 Applications: Immunohistochemistry (IHC) on FFPE tissue sections Staining Pattern: Cytoplasmic Species Reactivity: Human Use Cases: Identification of epithelial tumors, carcinoma subtyping, simple epithelial cell detection Formulation Options: Concentrated and ready-to-use Platform Compatibility: Suitable for both manual and automated IHC systems Quality Assurance: Batch-tested for specificity, sensitivity, and reproducibility The CK8/CK18 Antibody Cocktail (Clones B22.1 & B23.1) is an essential diagnostic and research tool for pathologists and scientists working in oncology, histopathology, and translational research. Its consistent performance and broad diagnostic utility make it ideal for accurate characterization of epithelial tumors across a wide range of tissue types.
B22.1&B23.1
The CK8 & CK18 Antibody Cocktail (Clones B22.1 & B23.1)
A peptide corresponding to the C-terminus of human Cytokeratin-7.
Immunohistochemistry (IHC) Western Blot (WB)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
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