Clathrin, Light Chain; Clone CLC/1421 (Concentrate) is a monoclonal antibody specifically developed to detect the light chain of clathrin, a key structural protein involved in the formation of clathrin-coated vesicles that mediate intracellular trafficking and endocytosis. Clone CLC/1421 provides strong and specific cytoplasmic staining in formalin-fixed, paraffin-embedded (FFPE) tissue sections, making it a valuable tool for studying vesicle transport pathways and cellular membrane dynamics. Clathrin light chain plays a regulatory role in vesicle assembly and disassembly, and its expression is observed in a wide range of cell types. This antibody is particularly useful in cell biology and cancer research, where altered vesicle trafficking is often implicated in disease progression. The concentrated format of Clone CLC/1421 allows for flexible protocol optimization, ensuring consistent and reproducible results across various experimental settings. Its high specificity and sensitivity make it a reliable marker for examining clathrin-mediated endocytosis and intracellular transport mechanisms.
Mouse.
Purified recombinant N-terminal fragment of human Clathrin Light Chain.
CLC/1421
IgG2b, kappa.
Reacts with human. Others not known.
HeLa cells. Placenta or prostate carcinoma.
Recognizes proteins of 31-44kDa, which are identified as Clathrin Light Chains (both A & B).
Cytoplasmic.