Claudin-4 Antibody (Rabbit Monoclonal)

Claudin-4 Antibody

The Claudin-4 Rabbit Monoclonal Antibody (Clone EP417) is a highly specific and sensitive antibody developed for the detection of Claudin-4, a transmembrane protein critical to the structure and function of tight junctions in epithelial cells. Claudin-4 plays a key role in regulating paracellular permeability and maintaining epithelial barrier integrity, and its overexpression is frequently associated with a wide range of carcinomas, including ovarian, pancreatic, gastric, prostate, and breast cancers. Due to its differential expression pattern, Claudin-4 has become a valuable biomarker in the diagnosis and classification of epithelial tumors, especially in distinguishing carcinomas from mesotheliomas and other non-epithelial malignancies. Clone EP417 is a rabbit monoclonal antibody that provides crisp, clean membranous staining with minimal background when applied to formalin-fixed, paraffin-embedded (FFPE) tissues in immunohistochemistry (IHC). Its superior affinity and epitope recognition ensure high performance in both diagnostic and research settings, delivering consistent results in routine pathology workflows and advanced cancer studies. The antibody is validated for use on both manual and automated staining platforms, and is offered in concentrated and ready-to-use formats, providing flexibility and convenience for laboratories of all sizes. Claudin-4 (EP417) is often used in diagnostic panels to aid in the differential diagnosis of tumors with epithelial origin, particularly in gynecologic and gastrointestinal pathology. It also serves as a valuable tool for studying tight junction dynamics, epithelial-mesenchymal transition (EMT), and tumor progression. With high batch-to-batch consistency and rigorous quality control, this antibody ensures reliable, reproducible staining results, making it a trusted reagent for pathologists, oncologists, and biomedical researchers worldwide. Whether used for clinical diagnostics or translational research, the Claudin-4 Rabbit Monoclonal Antibody (Clone EP417) offers exceptional performance, specificity, and clarity, making it an essential component of any IHC antibody panel focused on epithelial tumor evaluation.