CPS1 / Carbamoyl-Phosphate Synthetase 1 (Hepatocellular Marker); Clone SPM615 is a monoclonal antibody specifically developed to detect Carbamoyl-Phosphate Synthetase 1 (CPS1), a mitochondrial enzyme primarily expressed in hepatocytes. Clone SPM615 exhibits strong and specific cytoplasmic and mitochondrial staining in formalin-fixed, paraffin-embedded (FFPE) liver tissue sections, making it a highly reliable marker for hepatocellular differentiation. CPS1 plays a crucial role in the urea cycle, and its expression is largely restricted to liver tissue, making Clone SPM615 valuable in distinguishing hepatocellular carcinoma (HCC) from metastatic tumors of non-hepatic origin. This antibody is widely used in diagnostic pathology to aid in the identification and classification of liver tumors, supporting accurate diagnosis and guiding clinical management. The robust and specific staining pattern provided by Clone SPM615 makes it an essential tool in both clinical and research settings focused on liver pathology.
Mouse.
Recombinant human CPS1 protein.
SPM615
IgG1
Reacts with human and dog. Others not known.
HeLa cells, liver, or hepatocellular carcinoma (HCC).
This monoclonal antibody recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1).
Finely granular cytoplasmic.
