Cyclin B1 (G2- & M-phase Cyclin); Clone CCNB1/1098 (Concentrate) is a monoclonal antibody specifically developed to detect Cyclin B1, a regulatory protein essential for the progression of cells through the G2 phase and mitosis (M phase) of the cell cycle. Clone CCNB1/1098 provides strong nuclear staining in formalin-fixed, paraffin-embedded (FFPE) tissue sections, making it a valuable tool for immunohistochemical analysis of cell proliferation. Cyclin B1 plays a critical role in controlling the transition from G2 to M phase by activating cyclin-dependent kinases, and its overexpression is often associated with increased cellular proliferation and tumor aggressiveness. This antibody is widely used in cancer research and diagnostic pathology to assess proliferation status in various malignancies, including breast, lung, and colorectal cancers. The concentrated format allows for flexible dilution and protocol optimization to accommodate different laboratory requirements. Clone CCNB1/1098 is a reliable marker for studying cell cycle dynamics and tumor biology in both clinical and research settings.
Mouse
Recombinant human CCNB1 protein
CCNB1/1098
IgG1, kappa
Human and Mouse. Others not known.
Any human cell line in logarithmic growth phase, tonsil, or testis.
This antibody recognizes a protein of 55-62kDa, identified as cyclin B1.
Cytoplasmic & Nuclear
