Cyclin D1 (G1-Cyclin & Mantle Cell Marker); Clone CCND1/809 (Concentrate) is a monoclonal antibody specifically designed to detect Cyclin D1, a nuclear protein that plays a critical role in cell cycle regulation by controlling the transition from the G1 to S phase. Clone CCND1/809 provides strong nuclear staining in formalin-fixed, paraffin-embedded (FFPE) tissue sections, making it a reliable tool for immunohistochemical analysis. Cyclin D1 is overexpressed in a variety of tumors, most notably in mantle cell lymphoma (MCL), where it serves as a key diagnostic marker due to the characteristic t(11;14)(q13;q32) translocation. This antibody is also useful in the evaluation of certain breast, thyroid, and parathyroid tumors. The concentrated format allows for flexible dilution and protocol optimization to suit laboratory needs. With high specificity and sensitivity, Clone CCND1/809 is an essential reagent for identifying Cyclin D1 overexpression, aiding in accurate tumor diagnosis and classification in both hematopathology and solid tumor evaluation.
Mouse
Recombinant human CCND1 protein
CCND1/809
IgG2a, kappa
Human. Others not known.
T47D, ZR75, BT474, SKBR3, MCF-7, MDA-MB-453, HT29, Ramos, Jurkat or A431 cells. ~60% of mantle cell lymphomas and ~40% of breast carcinomas are positive.
This antibody recognizes a protein of 36kDa, identified as cyclin D1.
Nuclear