Cyclin E (G1/S-Phase Cyclin); Clone CCNE1/2460 is a monoclonal antibody developed to detect Cyclin E, a key nuclear protein involved in regulating the cell cycle, particularly the transition from the G1 to the S phase. Clone CCNE1/2460 exhibits strong nuclear staining in formalin-fixed, paraffin-embedded (FFPE) tissue sections and is widely used in immunohistochemistry to evaluate abnormal cell proliferation. Overexpression of Cyclin E is frequently associated with various malignancies, including breast, ovarian, and colorectal cancers, and is often linked to poor prognosis and aggressive tumor behavior. This antibody is particularly valuable for assessing cell cycle dysregulation in tumor specimens and can support the diagnosis and characterization of high-grade neoplasms. The concentrated format of Clone CCNE1/2460 allows for flexible protocol optimization and consistent performance, making it a powerful tool for both clinical diagnostics and cancer research applications.
Mouse
Recombinant fragment (around aa150-249) of human CDX2 protein (exact sequence is proprietary)
CCNE1/2460
IgG2b / Kappa
Human
Jurkat, MCF-7 or HeLa cells. Human breast or colon carcinoma.
Recognizes a protein of 53kDA, identified as Cyclin E.
Nucleus
