Product Overview
Clone: DE-K10
Cytokeratin 10 (Suprabasal Epithelial Marker) is a type I intermediate filament protein primarily expressed in the suprabasal layers of keratinized stratified squamous epithelia, such as the epidermis. It plays a critical role in maintaining structural integrity and cellular differentiation within mature epithelial tissues. Cytokeratin 10 serves as an important biomarker for epidermal differentiation and is commonly used in immunohistochemistry to evaluate normal skin, hyperproliferative skin disorders, and well-differentiated squamous cell carcinomas. Its expression is typically associated with terminal differentiation, making it a useful marker for distinguishing between keratinizing and non-keratinizing epithelial lesions. In diagnostic pathology, Cytokeratin 10 is valuable for characterizing cutaneous tumors and other lesions where keratinization status provides important diagnostic and prognostic information.
