Cytokeratin 10; Clone DE-K10 is a monoclonal antibody specifically developed to detect Cytokeratin 10, a type I intermediate filament protein predominantly expressed in the suprabasal layers of keratinized stratified squamous epithelia, such as the epidermis. Clone DE-K10 provides strong and specific cytoplasmic staining in formalin-fixed, paraffin-embedded (FFPE) tissue sections, making it a reliable tool for immunohistochemical analysis. This antibody is particularly useful for studying epidermal differentiation and for identifying keratinizing squamous cell carcinomas, as Cytokeratin 10 expression is typically associated with terminal epithelial differentiation. The concentrated format allows for flexible dilution and optimization in diverse laboratory protocols. Clone DE-K10 is an essential marker in both research and diagnostic pathology for distinguishing keratinizing from non-keratinizing epithelial lesions and for assessing the differentiation status of squamous epithelia.
Mouse
Cytoskeletal preparation extracted from human ectocervical epithelium.
DE-K10
IgG1, kappa
Human, Dog and Cat. Others not known.
Esophagus or Tonsil. A431, HeLa, MCF7 cells.
This antibody recognizes a protein of 56.5kDa identified as Cytokeratin 10.
Cytoplasmic
