The Cytokeratin 5/Cytokeratin 6 (CK-5/CK-6) Rabbit Monoclonal Antibody, using Clones EP24 and EP67, is a highly specific antibody cocktail developed for the immunohistochemical detection of basal epithelial cells and squamous differentiation in tissue samples. CK5 and CK6 are intermediate filament proteins expressed predominantly in the basal layer of stratified squamous epithelium and are important markers in the diagnosis of squamous cell carcinomas and basal-like carcinomas. This antibody pair offers strong and consistent cytoplasmic staining in formalin-fixed, paraffin-embedded (FFPE) tissues, making it a valuable tool for pathologists in the classification and differentiation of carcinomas, especially in lung, breast, head and neck, and skin cancers. The CK5/6 antibody cocktail aids in distinguishing squamous cell carcinoma from adenocarcinoma and other non-squamous malignancies. Validated for use in both manual and automated immunohistochemistry (IHC) platforms, Clones EP24 and EP67 provide excellent sensitivity and specificity with minimal background staining. The antibody is available in both concentrated and ready-to-use formulations, offering flexibility for various laboratory workflows. In addition to its diagnostic applications, this antibody cocktail is also useful in research focused on epithelial biology, tumor progression, and basal cell function. Its consistent performance and lot-to-lot reliability make it an essential reagent for clinical pathology labs and cancer research institutions. Key Features: Clones: EP24 & EP67 (Rabbit Monoclonal Antibodies) Target Proteins: Cytokeratin 5 and Cytokeratin 6 Applications: Immunohistochemistry (IHC) on FFPE tissues Localization: Cytoplasmic staining of basal epithelial cells Species Reactivity: Human Formulations: Available in concentrated and ready-to-use formats Use Cases: Diagnosis of squamous cell carcinoma, basal-like carcinoma, tumor subtyping Platform Compatibility: Manual and automated IHC staining systems Quality Assurance: Batch-tested for high specificity, sensitivity, and reproducibility The Cytokeratin 5/6 Rabbit Monoclonal Antibody (Clones EP24 & EP67) is an indispensable tool for accurate identification of basal epithelial markers and squamous differentiation in clinical and research pathology, ensuring precise tumor diagnosis and aiding in effective patient management.
EP24 and EP67
EP24 and EP67 reacts to both human CK-5 (Cytokeratin 5) and CK-6 (Cytokeratin 6).
A peptide corresponding to the C-terminus of Human Cytokeratin 5
Immunohistochemistry (IHC) Western Blot (WB)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
