The Cytokeratin 8 (KRT8) Antibody (Rabbit Monoclonal) is a highly specific and sensitive antibody designed for the detection of KRT8, a type II intermediate filament protein predominantly expressed in simple epithelial cells. This antibody is extensively validated for use in immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissue sections, making it an essential tool for both clinical diagnostics and research applications. KRT8 is a critical marker for identifying epithelial origin in a wide range of tissues including the liver, pancreas, breast, and gastrointestinal tract. It plays an important role in maintaining cytoskeletal integrity and is frequently expressed in various carcinomas, making it invaluable for tumor classification and differential diagnosis. The rabbit monoclonal format ensures enhanced affinity, specificity, and reproducibility with minimal background staining, providing clear and strong cytoplasmic labeling of CK8-positive cells. This antibody is optimized for consistent performance across multiple IHC platforms and detection systems. It is ideal for pathologists and researchers aiming to detect and characterize epithelial tumors, monitor disease progression, or study epithelial cell biology. The Cytokeratin 8 (KRT8) Rabbit Monoclonal Antibody offers reliable and reproducible results, aiding in accurate diagnostic interpretation and advancing research outcomes. Key Features: Clone: Rabbit Monoclonal Target: Cytokeratin 8 (KRT8) Application: Immunohistochemistry (IHC) on FFPE tissues Species Reactivity: Human Staining Pattern: Strong cytoplasmic expression in simple epithelial cells Use Cases: Identification of epithelial tumors, liver, breast, pancreas, and gastrointestinal cancers
Rabbit
Cytoskeleton preparation containing cytokeratin 8
GR34
IgG1
Human, Rat, Zebrafish. Others not known.
MCF-7 or A431 cells. Skin, colon, lung, or breast carcinoma.
CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19).
Cytoplasmic
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
