Product Overview

Clone: 34BH11

Cytokeratin 8 (KRT8); Clone 34BH11 (Concentrate) is a monoclonal antibody designed for the specific detection of Cytokeratin 8, a type II cytoskeletal protein expressed predominantly in simple epithelial cells and a wide range of epithelial-derived tumors. Clone 34BH11 demonstrates strong reactivity with KRT8 in formalin-fixed, paraffin-embedded (FFPE) tissues, making it highly suitable for immunohistochemical applications in diagnostic pathology. This antibody is particularly useful for identifying carcinomas of hepatic, pancreatic, and gastrointestinal origin, where KRT8 expression is typically retained. The concentrate format allows for flexible dilution and protocol optimization to suit specific laboratory conditions. Clone 34BH11 is valued for its high specificity and robust staining performance, providing clear and consistent results that assist in the classification and differential diagnosis of epithelial malignancies.

Specifications

Species

Mouse

Immunogen

Cytoskeletal extract of a human hepatocellular carcinoma cell line (Hep3B)

Clone

34BH11

Isotype

IgM, kappa

Species Reactivity

Human, Monkey, and Rabbit. Others not known.

Positive Control

MCF-7 or A431 cells. Skin, colon, lung, or breast carcinoma.

Specificity

Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19).

Cellular Localization

Cytoplasmic

Ordering Information

Format:

Volume:

  • Classification
  • RUO
  • Catalogue Number
  • G0178RP