Cytokeratin, Acidic (Type I or LMW) (Epithelial Marker)

The Cytokeratin, Acidic Monoclonal Antibody [Clone KRTL] is a mouse monoclonal antibody specifically designed to detect low molecular weight (LMW) cytokeratins, also classified as type I (acidic) cytokeratins, which are predominantly found in simple epithelial tissues. This antibody is a valuable tool in the diagnosis of epithelial tumors, especially adenocarcinomas and other glandular neoplasms. Clone KRTL demonstrates strong cytoplasmic staining in epithelial cells and is widely used for immunohistochemical evaluation of formalin-fixed, paraffin-embedded (FFPE) tissue specimens.

Specifications

Species

Mouse

Immunogen

Keratin preparation from a human carcinoma

Clone

KRTL

Isotype

IgG1, kappa

Species Reactivity

Human. Shows broad species reactivity.

Positive Control

Skin, Squamous cell carcinoma (SCC).

Specificity

This antibody recognizes the 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19) keratins of the acidic (Type I or LMW) subfamily.

Cellular Localization

Cytoplasmic