Cytokeratin, Acidic (Type I or LMW) (Epithelial Marker)

The Cytokeratin Acidic (Type I) Monoclonal Antibody [Clone AE-1] is a mouse-derived monoclonal antibody that specifically binds to a broad spectrum of low molecular weight (LMW), acidic cytokeratins, including CK10, CK14, CK15, CK16, and CK19. These keratins are predominantly expressed in simple epithelial tissues and their associated carcinomas. Clone AE-1 is widely used in diagnostic pathology to confirm epithelial origin in neoplastic tissue, especially when used in combination with Clone AE-3 (which targets basic cytokeratins), providing nearly complete pan-cytokeratin coverage.

Specifications

Species

Mouse

Immunogen

Human epidermal keratin

Clone

AE-1

Isotype

IgG1, kappa

Species Reactivity

Human, Monkey, Cow, Dog, Rabbit, Mouse, Rat, Chicken, Turtle. Others not known.

Positive Control

Skin, Squamous cell carcinoma (SCC).

Specificity

This antibody recognizes the 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19) keratins of the acidic (Type I or LMW) subfamily.

Cellular Localization

Cytoplasmic