Cytokeratin Cocktail (AE1&AE3)

Cytokeratin Cocktail (AE1&AE3)

The Cytokeratin Cocktail AE1/AE3 is a widely used, broad-spectrum mouse monoclonal antibody mixture designed to detect a wide range of cytokeratin proteins found in epithelial tissues. This antibody cocktail combines two clones — AE1, which recognizes acidic (Type I) cytokeratins, and AE3, which targets basic to neutral (Type II) cytokeratins — providing comprehensive coverage for the identification of most epithelial-derived cells and carcinomas in formalin-fixed, paraffin-embedded (FFPE) tissues. This antibody is especially valuable in immunohistochemistry (IHC) applications where the detection of a broad range of cytokeratins is essential for confirming epithelial origin in undifferentiated tumors, metastatic cancers, and poorly differentiated carcinomas. AE1/AE3 is commonly used in pathology laboratories for the differential diagnosis of epithelial neoplasms, making it an essential marker in routine diagnostic panels. The AE1/AE3 cocktail provides strong, diffuse cytoplasmic staining with minimal background, ensuring clear and interpretable results across various tissue types. It is validated for use in both manual and automated IHC platforms, and is available in concentrated and ready-to-use formats for convenience and workflow efficiency. Key Features: Clones: AE1 (Type I) & AE3 (Type II) Host Species: Mouse Monoclonal Target Proteins: Broad-spectrum cytokeratins (CK1–CK8, CK10, CK14–CK16, CK19) Applications: Immunohistochemistry (IHC) on FFPE tissues Localization: Cytoplasmic Species Reactivity: Human Formulations: Concentrated and ready-to-use Use Cases: Identification of epithelial tumors, differential diagnosis of carcinoma, metastatic tumor typing Platform Compatibility: Compatible with manual and automated IHC systems Quality Control: Validated for high specificity, sensitivity, and reproducibility The AE1/AE3 Cytokeratin Cocktail is a gold-standard reagent in diagnostic histopathology, offering reliable and consistent staining of a wide variety of epithelial tissues. It is an indispensable tool for pathologists and researchers working in oncology, tumor classification, and cancer diagnostics.