The Cytokeratin High Molecular Weight (HMW) Antibody, Clone AE3, is a highly specific mouse monoclonal antibody developed for the detection of high molecular weight cytokeratins in epithelial tissues. This antibody targets Type II (basic to neutral) cytokeratins, including CK1 through CK8, making it a valuable marker for identifying stratified squamous epithelium and a wide range of epithelial-derived tumors. Clone AE3 binds to cytokeratins commonly found in keratinizing and non-keratinizing epithelial tissues, offering strong cytoplasmic staining with minimal background in formalin-fixed, paraffin-embedded (FFPE) tissue samples. It is particularly useful in immunohistochemistry (IHC) for diagnosing squamous cell carcinoma, urothelial carcinoma, and for distinguishing epithelial tumors from non-epithelial malignancies such as sarcomas or lymphomas. This antibody is validated for use on both manual and automated IHC platforms and is available in concentrated and ready-to-use formulations to meet the needs of clinical laboratories and research institutions. Its consistent performance, high specificity, and broad reactivity make AE3 an essential tool in routine pathology and tumor typing. Key Features: Clone: AE3 Host Species: Mouse Monoclonal Target: High Molecular Weight Cytokeratins (CK1–CK8) Applications: Immunohistochemistry (IHC) on FFPE tissues Staining Pattern: Cytoplasmic Species Reactivity: Human Formulations: Concentrated and ready-to-use formats available Use Cases: Identification of epithelial tumors, squamous cell carcinoma, urothelial carcinoma, tumor differentiation Platform Compatibility: Suitable for manual and automated IHC staining systems Quality Control: Batch-tested for sensitivity, specificity, and reproducibility The Cytokeratin HMW Antibody (Clone AE3) is a reliable and widely used reagent for detecting epithelial differentiation, aiding in the accurate diagnosis and classification of carcinomas. Its broad reactivity to high molecular weight keratins ensures dependable results across a variety of tissue types and tumor profiles, making it a trusted marker in histopathology and cancer research. Gene Bio Solution is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Skin, Tonsil , Prostate or Cervix
Cytoplasmic
IgG
Cytoskeletal extract from human epidermis containing high molecular weight (Type II) cytokeratins.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
