Cytokeratin, HMW
Clone: 34βE12
Cytokeratin HMW [34βE12] is a monoclonal antibody that targets high-molecular-weight cytokeratins, specifically cytokeratins 1, 5, 10, and 14, which are intermediate filament proteins expressed predominantly in the basal and suprabasal layers of stratified squamous epithelia. This antibody is widely used in diagnostic pathology to identify and differentiate epithelial cells of squamous origin from other cell types. It is particularly valuable in the evaluation of carcinomas, such as distinguishing prostate basal cells from malignant glands, and in identifying squamous cell carcinomas in various tissues. The 34βE12 antibody helps pathologists detect the presence or absence of basal cell layers, aiding in the diagnosis of malignancies, including prostate and breast cancers, by highlighting the architecture and differentiation status of epithelial tissues. Its specificity for high-molecular-weight cytokeratins makes it an essential tool for tumor classification and prognosis assessment.
