The Cytokeratin Multi (Basic) Monoclonal Antibody [Clone AE-3] is a mouse monoclonal antibody that reacts with several Type II (basic/neutral) cytokeratins, primarily cytokeratin 1, 3, 4, 5, 6, 7, and 8, which are expressed in various epithelial tissues. These cytokeratins are typically high molecular weight (HMW) and play essential roles in structural support and epithelial differentiation. Clone AE-3 is ideal for detecting basic cytokeratins in a broad spectrum of epithelial cells, making it a reliable tool for identifying epithelial tumors and differentiating carcinoma subtypes.
Mouse
Human epidermal keratin
AE-3
IgG1, kappa
Human, Monkey, Cow, Dog, Rabbit, Mouse, Rat, Chicken. Others not known.
Epithelial cells, skin or adenocarcinomas.
This antibody recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8).
Cytoplasmic