The Cytokeratin 8/18 Antibody (Rabbit Monoclonal) is a highly specific and sensitive antibody engineered to detect both Cytokeratin 8 (KRT8) and Cytokeratin 18 (KRT18), essential intermediate filament proteins expressed predominantly in simple epithelial cells. This antibody is rigorously validated for immunohistochemistry (IHC) applications on formalin-fixed, paraffin-embedded (FFPE) tissue samples, making it a critical tool in both clinical pathology and research settings. Cytokeratin 8 and 18 serve as key biomarkers for epithelial tissue integrity and are widely used in diagnosing and classifying various epithelial-derived tumors, including those of the liver, breast, pancreas, and gastrointestinal tract. The rabbit monoclonal format ensures superior affinity, enhanced specificity, and reduced background staining compared to traditional antibodies, providing crisp, clear cytoplasmic staining of CK8/18-positive cells. This antibody is compatible with a broad range of detection systems and automated IHC platforms, ensuring reliable and reproducible staining results. It is especially valuable for pathologists and researchers involved in tumor identification, differential diagnosis, and studies focused on epithelial cell biology. The Cytokeratin 8/18 Rabbit Monoclonal Antibody is an indispensable reagent for enhancing diagnostic accuracy and advancing cancer research. Key Features: Clone: Rabbit Monoclonal Targets: Cytokeratin 8 (KRT8) and Cytokeratin 18 (KRT18) Application: Immunohistochemistry (IHC) on FFPE tissues Species Reactivity: Human Staining Pattern: Strong cytoplasmic expression in simple epithelial cells Use Cases: Detection and classification of epithelial tumors in liver, breast, pancreas, and gastrointestinal tissues
For Research Use Only.
Rabbit
Keratin preparation from a human carcinoma ; PMC human breast carcinoma cells
RM88
IgG1/Kappa
Human
Colon, lung or breast carcinoma , Skin
Cytoplasm, Nucleoplasm, Nucleus, Nucleus matrix
Non-sterile product; store according to recommended guidelines.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
