Decorin, Clone DCN/3523, is a monoclonal antibody designed for the specific detection of decorin, a small leucine-rich proteoglycan found in the extracellular matrix of various connective tissues. Decorin plays a key role in collagen fibrillogenesis, regulation of cell proliferation, and modulation of growth factor activity, particularly transforming growth factor-beta (TGF-β). The DCN/3523 clone is valuable in both research and diagnostic settings, especially in studies related to fibrosis, wound healing, and certain tumor microenvironments where decorin expression may be altered. This antibody exhibits strong and specific staining patterns, primarily in the stromal and connective tissue compartments, and can be used in formalin-fixed, paraffin-embedded tissue sections. Its performance makes it a useful marker in histological analysis of tissue remodeling, fibrotic disorders, and cancer pathogenesis.
Mouse
Recombinant human Decorin protein fragment (aa212-336) (exact sequence is proprietary)
DCN/3523
IgG2b / Kappa
Human
Human prostate or skin tissue (IHC).
Recognized Decorin, a small leucine-rich proteoglycan (SLRP) family member that consists of glycosaminoglycan chain-containing core protein.
Extracellular matrix, Extracellular space, Secreted
