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Double Stranded DNA (dsDNA) (Nuclear Marker)

The Double Stranded DNA (dsDNA) Antibody [Clone 121-3] is a highly specific mouse monoclonal antibody developed to detect native dsDNA in a variety of applications including immunohistochemistry, immunocytochemistry, ELISA, and flow cytometry. This antibody serves as a valuable tool for identifying nuclear material and evaluating cell integrity, proliferation, or apoptotic processes. Clone 121-3 binds specifically to conformational epitopes on native dsDNA, enabling the detection of nuclear DNA in intact cells and tissue sections. It is widely used in autoimmune research, particularly for studies related to systemic lupus erythematosus (SLE), and as a nuclear counterstain or nuclear marker in various assays.

Specifications

Species

Mouse

Immunogen

Nuclei of Raji Burkitt's cells

Clone

121-3

Isotype

IgG3, kappa

Species Reactivity

Human. Others not known.

Positive Control

Tonsil

Specificity

This antibody recognizes the double stranded DNA in human cells. It can be used to stain the nuclei in cell or tissue preparations and can be used as a nuclear marker in human cells.

Cellular Localization

Nuclear

Ordering Information

Format:

Volume:

  • Classification
  • RUO
  • Catalogue Number
  • G0417RP