The Double Stranded DNA (dsDNA) Antibody [Clone 121-3] is a highly specific mouse monoclonal antibody developed to detect native dsDNA in a variety of applications including immunohistochemistry, immunocytochemistry, ELISA, and flow cytometry. This antibody serves as a valuable tool for identifying nuclear material and evaluating cell integrity, proliferation, or apoptotic processes. Clone 121-3 binds specifically to conformational epitopes on native dsDNA, enabling the detection of nuclear DNA in intact cells and tissue sections. It is widely used in autoimmune research, particularly for studies related to systemic lupus erythematosus (SLE), and as a nuclear counterstain or nuclear marker in various assays.
Mouse
Nuclei of Raji Burkitt's cells
121-3
IgG3, kappa
Human. Others not known.
Tonsil
This antibody recognizes the double stranded DNA in human cells. It can be used to stain the nuclei in cell or tissue preparations and can be used as a nuclear marker in human cells.
Nuclear