The Double Stranded DNA (dsDNA) Antibody [Clone AE-2] is a mouse monoclonal antibody designed to recognize and bind to native double-stranded DNA (dsDNA). This antibody is primarily used as a nuclear marker in both normal and disease tissues, and it plays a significant role in studies of cell proliferation, apoptosis, and autoimmunity—especially systemic lupus erythematosus (SLE). Clone AE-2 exhibits strong nuclear reactivity in human cells and tissues, making it an ideal reagent for immunohistochemistry (IHC), immunocytochemistry (ICC), ELISA, and flow cytometry. It provides clean, crisp nuclear staining and is particularly useful in detecting nuclear morphology, DNA integrity, and autoantibody binding in autoimmune panels.
Mouse
Nuclei of Raji Burkitt's cells
AE-2
IgG3, kappa
Human. Others not known.
Tonsil
This antibody recognizes the double stranded DNA in human cells. It can be used to stain the nuclei in cell or tissue preparations and can be used as a nuclear marker in human cells.
Nuclear