DPC4 SMAD4 Antibody

DPC4 SMAD4

The DPC4 SMAD4 Antibody (Clone SMD46) is a highly specialized monoclonal antibody designed to detect SMAD4 (also known as DPC4), a critical tumor suppressor protein involved in the Transforming Growth Factor-beta (TGF-β) signaling pathway. SMAD4 plays an essential role in regulating cell growth, apoptosis, and differentiation, and mutations in this gene are often implicated in various cancers, including pancreatic, colorectal, and biliary tract cancers. This antibody is specifically optimized for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissue samples, enabling reliable detection and visualization of SMAD4 expression in tissue sections. Clone SMD46 recognizes an epitope on the SMAD4 protein, offering high specificity and sensitivity with minimal background staining. The strong and clear staining pattern allows pathologists to assess the presence or absence of SMAD4 protein expression, which can be crucial for tumor profiling and prognostic evaluation. Loss of SMAD4 expression is often associated with poor prognosis, and its detection can aid in the identification of patients who may benefit from targeted therapeutic interventions. This antibody is an indispensable tool in both clinical diagnostics and research applications, providing valuable insights into SMAD4's role in tumorigenesis and its potential as a therapeutic target. With its consistent performance and ease of use, the DPC4 SMAD4 Antibody (Clone SMD46) is an excellent choice for researchers and clinicians focused on cancer biomarker discovery, cancer pathway analysis, and personalized medicine.