The Ep-CAM / CD326 Mouse Monoclonal Antibody [Clone HEA125] is a well-established tool for detecting epithelial cell adhesion molecule (Ep-CAM / CD326), a transmembrane glycoprotein expressed on epithelial tissues and widely overexpressed in carcinomas of epithelial origin. This antibody demonstrates strong membranous staining in epithelial cells and is extensively used in tumor diagnostics, circulating tumor cell (CTC) detection, and epithelial lineage identification. Clone HEA125 is among the most widely referenced Ep-CAM clones in both clinical and research settings due to its high sensitivity and specificity for epithelial-derived neoplasms.
Mouse
Human colon cancer HT29 cells
HEA125
IgG1, kappa
Human. Others not known.
HT29 cells or breast tumor.
Recognizes a 40-43kDa transmembrane epithelial glycoprotein, identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM).
Cell surface