The Ep-CAM / CD326 Mouse Monoclonal Antibody [Clone MOC-31] is a widely validated tool for identifying Epithelial Cell Adhesion Molecule (Ep-CAM / CD326), a membrane glycoprotein expressed on most epithelial tissues and carcinomas. Clone MOC-31 is known for producing strong membranous staining in epithelial-derived cells and tumors, with minimal cross-reactivity with mesenchymal or hematopoietic cells. This antibody is extensively used for differentiating carcinomas from mesotheliomas, identifying metastatic adenocarcinomas, and detecting circulating tumor cells (CTCs) in clinical and research settings.
Mouse
Neuraminidase treated GLS-1 human small cell lung carcinoma cells
MOC-31
IgG1, kappa
Human. Does not react with Rat. Others not known.
HT29 cells or breast tumor.
The epitope of this antibody is located in the first EGF-like repeat domain (EGF1) between amino acids 27-59 of Ep-CAM.
Cell surface