The Ep-CAM / CD326 Mouse Monoclonal Antibody [Clone EGP40/1372] specifically targets the extracellular domain of Ep-CAM (Epithelial Cell Adhesion Molecule), also known as CD326. This clone provides strong and selective membranous staining of epithelial cells and epithelial-derived tumors, making it a valuable tool in diagnostic pathology for identifying and classifying carcinomas. Clone EGP40/1372 recognizes an epitope on the EGP40 antigen, a highly expressed glycoprotein on the surface of normal epithelial tissues and a wide variety of epithelial cancers.
Mouse
Recombinant fragment from the extracellular domain of human EpCAM protein (around aa100-224) (exact sequence is proprietary)
EGP40/1372
IgG1
Human
MCF-7, HT29 cells or Ovarian carcinoma
Recognizes EGP40, a 40-43kDA transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM).
Cell junction, Cell surface, Lateral cell membrane, Tight junction