The Ep-CAM / CD326 (Extracellular Domain) Antibody [Clone Ber-EP4] is a highly specific mouse monoclonal antibody that recognizes an extracellular epitope of the epithelial cell adhesion molecule (Ep-CAM / CD326). This clone is one of the most clinically validated and widely used antibodies for identifying epithelial neoplasms, especially in distinguishing carcinomas from mesotheliomas and non-epithelial tumors. Ber-EP4 binds strongly to most epithelial cells and adenocarcinomas, while showing little to no reactivity with mesothelial cells, making it an essential tool in differential diagnosis.
Mouse
Human breast cancer MCF-7 cells
Ber-EP4
IgG1 / Kappa
Human
MCF-7 or HT29 cells. Breast tumor.
Recognizes a 40-43kDa transmembrane epithelial glycoprotein, identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM).
Cell junction, Lateral cell membrane, Tight junction
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