The Estrogen Receptor (ER) Antibody [Clone ER505] is a mouse monoclonal antibody designed for the detection of estrogen receptor alpha (ERα), a key nuclear transcription factor involved in mediating estrogen hormone signaling. ER is a well-established biomarker used in the diagnosis, prognosis, and treatment planning of hormone-dependent cancers, particularly breast carcinoma. Clone ER505 provides reliable nuclear staining in formalin-fixed, paraffin-embedded tissues and is an ideal choice for evaluating ER status in breast and endometrial carcinomas. Its high specificity and sensitivity enable clear stratification of ER-positive versus ER-negative tumors, guiding hormone therapy decisions such as tamoxifen or aromatase inhibitor use.
Mouse
Recombinant human Estrogen Receptor alpha protein (aa 2-185)
ER505
IgG1, kappa
Human. Others not known.
MCF-7 cells or breast cancers.
This antibody is specific to ER alpha and shows minimal cross-reaction with other members of the family.
Nuclear