The Factor XIIIa Antibody (Rabbit Monoclonal, Clone EP3372) from GeneBioSolution is a high-quality antibody optimized for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues. Factor XIIIa is a transglutaminase enzyme expressed by dermal dendrocytes and histiocytes, making it a highly valuable marker in dermatopathology and soft tissue tumor diagnostics. This antibody provides sensitive and specific detection of Factor XIIIa, producing strong cytoplasmic staining with minimal background. The EP3372 clone is particularly useful for identifying dermal dendrocytes, which helps distinguish dermatofibroma (benign fibrous histiocytoma) from other cutaneous spindle cell lesions such as dermatofibrosarcoma protuberans (DFSP). In addition to dermatopathology, Factor XIIIa staining can aid in the classification of histiocytic lesions, fibrohistiocytic tumors, and certain soft tissue neoplasms, making it a critical diagnostic antibody in surgical pathology. Clinical & Research Applications Differentiation of dermatofibroma vs. DFSP Identification of dermal dendrocytes and histiocytes Evaluation of fibrohistiocytic lesions and soft tissue tumors Research on dermal immune response and wound healing Key Features Clone: EP3372 (Rabbit Monoclonal) Application: Immunohistochemistry (IHC) on FFPE tissues Target Protein: Factor XIIIa – dermal dendrocyte marker Diagnostic Utility: Dermatofibroma, DFSP, fibrohistiocytic tumors, histiocytic lesions Performance: High sensitivity, reproducible staining, low background
Rabbit
A synthetic peptide corresponding to an epitope of the human Factor XIIIa protein was used as the immunogen for Rabbit Monoclonal Antibody (Clone EP3372).
EP3372
IgG1, kappa
Human and Cynomolgus Monkey. Others not known.
Tissue Controls: Skin, dermatofibroma, and other fibrohistiocytic lesions (FFPE sections) serve as reliable positive controls. Cellular Expression: Strong cytoplasmic staining is expected in dermal dendrocytes.
The Factor XIIIa (Clone EP3372) antibody shows high specificity and sensitivity for Factor XIIIa, a dermal dendrocyte marker
Cytoplasmic
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
