Product Overview
Clone: FSCN1/417
Fascin-1 (Reed-Sternberg Cell Marker), Clone FSCN1/417, is a monoclonal antibody used in immunohistochemistry for the detection of fascin-1, an actin-bundling protein involved in cell motility and cytoskeletal organization. This antibody specifically targets fascin-1, which is notably overexpressed in Reed-Sternberg cells of classical Hodgkin lymphoma, making it a valuable diagnostic marker for distinguishing this lymphoma from other lymphoid and non-lymphoid malignancies. Clone FSCN1/417 demonstrates strong cytoplasmic staining in fascin-positive cells and is particularly useful when included in a panel of markers to confirm the diagnosis of classical Hodgkin lymphoma. It is typically applied to formalin-fixed, paraffin-embedded (FFPE) tissue sections and is compatible with various detection systems. As a concentrated antibody, it requires appropriate dilution and optimization based on specific laboratory protocols.
