The Fascin Antibody (Mouse Monoclonal, Clone 55-K2) from GeneBioSolution is a high-quality antibody validated for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues. Fascin is an actin-bundling protein that plays a crucial role in cell motility, migration, and cytoskeletal organization. This antibody delivers sensitive and specific detection of fascin, producing strong cytoplasmic staining in dendritic cells and selected epithelial tissues with minimal background. The 55-K2 clone is widely recognized in diagnostic pathology as a reliable marker for dendritic cell identification and tumor characterization. In clinical applications, fascin is a valuable biomarker for the diagnosis of dendritic cell tumors, Hodgkin’s lymphoma, and certain carcinomas. It is also used in cancer research to study tumor invasiveness, metastasis, and epithelial–mesenchymal transition (EMT). GeneBioSolution ensures all antibodies undergo rigorous quality control and validation, guaranteeing lot-to-lot consistency, high sensitivity, and reproducible IHC performance on both manual and automated staining platforms. Clinical & Research Applications Marker for dendritic cells in normal and neoplastic tissues Diagnostic aid in Hodgkin’s lymphoma and dendritic cell tumors Assessment of fascin overexpression in carcinomas (breast, colorectal, gastric, and pancreatic cancers) Research on cell motility, EMT, and metastasis pathways Key Features Clone: 55-K2 (Mouse Monoclonal) Application: Immunohistochemistry (IHC) on FFPE tissues Target Protein: Fascin – actin-bundling cytoskeletal protein Diagnostic Utility: Dendritic cell tumors, Hodgkin’s lymphoma, epithelial carcinomas Performance: Strong cytoplasmic staining, high specificity, reproducible results
Mouse
Recombinant fragment of the human Fascin protein was used as the immunogen for the Mouse Monoclonal Antibody (Clone 55-K2)
55-k2
IgG1, kappa
Human and Monkey. Others not known.
Tissues: Tonsil, lymph node, dendritic cell–rich tissues, and Hodgkin’s lymphoma sections serve as reliable positive controls. Expected Staining: Strong cytoplasmic staining in dendritic cells and selected epithelial tissues.
The Fascin Antibody (Clone 55-K2) shows high specificity for fascin, an actin-bundling protein. Validated by IHC in FFPE human tissues. Distinguishes dendritic cell tumors and Hodgkin’s lymphoma from other hematologic malignancies. No cross-reactivity with unrelated cytoskeletal proteins detected under tested conditions.
Fascin is localized predominantly in the cytoplasm, where it associates with actin bundles. Expression is enriched in dendritic cells, activated endothelial cells, and various epithelial tumors
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
