The FOXP1 Antibody (Rabbit Monoclonal, Clone EP137) from GeneBioSolution is a high-quality antibody designed for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues. FOXP1 (Forkhead box protein P1) is a transcription factor belonging to the FOX family, playing a key role in lymphocyte development, cell differentiation, and oncogenesis. This antibody provides sensitive and specific nuclear staining of FOXP1, with minimal background interference. The EP137 clone is widely recognized as a reliable marker for the identification of B-cell lymphomas, including diffuse large B-cell lymphoma (DLBCL) and marginal zone lymphoma, where FOXP1 expression is often associated with poor prognosis and aggressive tumor biology. In addition to hematopathology, FOXP1 is expressed in several solid tumors, making it a valuable biomarker for cancer research. It has also been implicated in immune regulation and transcriptional control, providing applications in both diagnostic and translational research. GeneBioSolution ensures all antibodies, including FOXP1 EP137, undergo rigorous validation across multiple tissue types, guaranteeing lot-to-lot consistency, strong nuclear staining, and compatibility with manual and automated IHC systems. Clinical & Research Applications Diagnostic aid in B-cell lymphomas (DLBCL, marginal zone lymphoma, MALT lymphoma) Biomarker for tumor aggressiveness and prognosis Evaluation of FOXP1 expression in solid tumors Research into immune system development and transcriptional regulation Key Features Clone: EP137 (Rabbit Monoclonal) Application: Immunohistochemistry (IHC) on FFPE tissues Target Protein: FOXP1 transcription factor Diagnostic Utility: B-cell lymphomas, hematologic malignancies, solid tumors A synthetic peptide corresponding to an epitope of the human FOXP1 protein was used as the immunogen for the Rabbit Monoclonal Antibody (Clone EP137)
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Tonsil, spleen, and lymphoma tissues (e.g., diffuse large B-cell lymphoma) serve as reliable positive controls. Expected Staining: Distinct nuclear staining of B-cells in germinal centers and neoplastic B-cell populations.
Recommended detection using an HRP/DAB chromogenic system, which produces a brown nuclear stain in FOXP1-positive cells. Compatible with standard IHC visualization systems (HRP or AP based), both manual and automated. Use of a suitable counterstain (e.g., hematoxylin) is advised to highlight tissue morphology
IgG
A synthetic peptide corresponding to an epitope of the human FOXP1 protein was used as the immunogen for the Rabbit Monoclonal Antibody (Clone EP137)
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
