The Glucagon Antibody (Rabbit Monoclonal, Clone EP74) from GeneBioSolution is a premium-quality antibody validated for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues. Glucagon is a peptide hormone produced by pancreatic α-cells, playing a key role in glucose metabolism, homeostasis, and endocrine signaling. This antibody provides sensitive and specific detection of glucagon, producing strong cytoplasmic staining in pancreatic α-cells with minimal background. The EP74 clone is widely used in both diagnostic pathology and research for identifying islet cell tumors, glucagonomas, and pancreatic neuroendocrine tumors (PanNETs). In addition to diagnostic utility, this antibody supports endocrine and metabolic research, making it a valuable tool for studying pancreatic function, glucose regulation, diabetes, and hormone-secreting neoplasms. All GeneBioSolution antibodies undergo strict quality control and validation, ensuring lot-to-lot consistency, high specificity, and reproducible IHC performance on both manual and automated staining systems. Clinical & Research Applications Identification of pancreatic α-cells in normal pancreas Diagnostic marker for glucagon-secreting tumors (glucagonomas) Evaluation of pancreatic neuroendocrine tumors (PanNETs) Research on glucose metabolism, endocrine signaling, and diabetes Key Features Clone: EP74 (Rabbit Monoclonal) Application: Immunohistochemistry (IHC) on FFPE tissues Target Protein: Glucagon – pancreatic α-cell hormone Diagnostic Utility: Glucagonoma, pancreatic neuroendocrine tumors, endocrine pathology Performance: Strong cytoplasmic staining, high sensitivity, reproducible results
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Pituitary
Produces strong cytoplasmic staining in pancreatic α-cells. Expected pattern: granular cytoplasmic positivity in islets of Langerhans. Negative in non-α-cell populations, ensuring high specificity in pancreatic tissue.
IgG2b /κ
A recombinant human Growth Hormone (GH) fragment (aa 58-187)
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
