The GLUT1 Antibody (Rabbit Monoclonal, Clone EP141) from GeneBioSolution is a high-quality antibody optimized for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues. GLUT1 (Glucose Transporter 1) is a membrane protein responsible for facilitating basal glucose uptake and is widely expressed in erythrocytes, endothelial cells, and tumor cells under hypoxic conditions. This antibody provides sensitive and specific membranous staining of GLUT1, with minimal background. The EP141 clone is extensively used in diagnostic pathology to evaluate tumors with increased glucose metabolism, including renal cell carcinoma, colorectal carcinoma, breast carcinoma, and brain tumors. GLUT1 is also useful as a marker of tissue hypoxia and is frequently upregulated in malignant neoplasms. In addition to oncology, GLUT1 plays a vital role in studies of metabolism, ischemia, and neurobiology, making this antibody a valuable tool for both diagnostic and research applications. All GeneBioSolution antibodies undergo strict validation and quality control, ensuring lot-to-lot consistency, reproducible staining, and compatibility with manual and automated IHC platforms. Clinical & Research Applications Diagnostic aid in renal cell carcinoma, colorectal carcinoma, and breast carcinoma Marker of tumor hypoxia and metabolic reprogramming Evaluation of GLUT1 expression in brain tumors and ischemic lesions Research on glucose transport, cancer metabolism, and hypoxia signaling
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Adenocarcinoma
Cell surface
IgG2a/κ
Recombinant full-length human GLUT-1 protein
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
