GLUT-1

GLUT-1

GeneBio’s recombinant mouse antibody recognizes GLUT-1 (Glucose Transporter Isoform 1), the major glucose transport carrier protein in the mammalina blood-brain barrier. The GLUT-1 antibody binds a protein of 55kDa. Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. There are many types of glucose transport carrier proteins, designated as GLUT-1 to GLUT-12. GLUT-1 is a major glucose transporter in the mammalian blood-brain barrier. GLUT-1 is expressed in high density on the membranes of human erythrocytes and the brain capillaries that comprise the blood-brain barrier. GLUT-1 is expressed at variable levels in many human tissues. Overexpression of GLUT-1 has been linked to tumor progression or poor survival of patients with carcinomas of the colon, breast, cervical, lung, bladder and mesothelioma. GLUT-1 is a sensitive and specific marker for the differentiation of malignant mesothelioma (positive) from reactive mesothelium (negative).