Glutamine Synthetase (Mouse Monoclonal)

Glutamine Synthetase

The Glutamine Synthetase Antibody (Mouse Monoclonal, Clone GS-6) from GeneBioSolution is a high-quality antibody validated for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues. Glutamine Synthetase (GS) is a key metabolic enzyme that catalyzes the conversion of glutamate and ammonia to glutamine, playing a central role in nitrogen metabolism, neurotransmission, and tumor biology. This antibody provides sensitive and specific cytoplasmic staining of glutamine synthetase, with minimal background. The GS-6 clone is widely used in diagnostic pathology, especially for the evaluation of liver lesions where glutamine synthetase is a reliable marker for focal nodular hyperplasia (FNH), hepatocellular carcinoma (HCC), and other hepatic neoplasms. In addition to hepatic pathology, glutamine synthetase is an important marker in neuroscience research, as it is expressed in astrocytes and involved in glutamate detoxification and neurotransmitter regulation. It is also increasingly studied in tumor metabolism and cancer biology, where glutamine dependency is a hallmark of tumor progression. All GeneBioSolution antibodies undergo stringent validation and quality control, ensuring lot-to-lot consistency, high specificity, and reproducible results on both manual and automated IHC platforms. Clinical & Research Applications Diagnostic aid in liver pathology, including FNH and hepatocellular carcinoma Marker for astrocytes in neuroscience and brain tissue studies Research into glutamine metabolism, nitrogen balance, and neurotransmission Studies of tumor metabolism and glutamine dependency in cancer