The Glypican-3 (GPC3) Mouse Monoclonal Antibody (Clone 1G12) is a highly specific tool for the detection of Glypican-3, a membrane-bound heparan sulfate proteoglycan overexpressed in hepatocellular carcinoma (HCC) and other malignant liver tumors. GPC3 is virtually absent in benign liver lesions and normal liver tissue, making it a powerful immunohistochemical marker to distinguish malignant from non-malignant hepatic conditions. Clone 1G12 offers crisp, cytoplasmic and membranous staining in HCC specimens and is widely used in diagnostic pathology for liver tumor classification.
Mouse
A recombinant fragment containing amino acids 511-580 of human glypican-3
1G12
IgG1, kappa
Human. Others not known.
293T cells or Hepatocellular carcinoma.
Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm's tumor.
Cytoplasmic