The Glypican-3 antibody [1G12] is a monoclonal antibody that targets Glypican-3 (GPC3), a heparan sulfate proteoglycan that is anchored to the cell membrane and plays a key role in cell signaling, growth, and development. GPC3 is highly expressed in hepatocellular carcinoma (HCC) and is used as a diagnostic and prognostic marker in liver cancer. The [1G12] clone is commonly employed in immunohistochemistry (IHC) and flow cytometry to detect GPC3 expression in tissue samples, particularly in liver tumors. It is also used to differentiate hepatocellular carcinoma from other liver lesions, as GPC3 is often overexpressed in HCC but not in normal liver tissue or benign liver lesions. Additionally, GPC3 has been implicated in oncogenesis and is considered a potential therapeutic target. This antibody is a valuable tool in both diagnostic pathology and cancer research.
Mouse
Monoclonal
1G12
IgG1
WB, IHC-P,FCM, IP
Human
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
A fragment containing the last 70 amino acids of human core glypican-3 protein.