The GnRH-Receptor (LH-RH Receptor) Mouse Monoclonal Antibody (Clone F1G4) is a highly specific reagent targeting the Gonadotropin-Releasing Hormone Receptor (GnRH-R / LH-RH Receptor). This receptor plays a pivotal role in reproductive hormone regulation via the hypothalamic-pituitary-gonadal axis. It is found in anterior pituitary cells and also aberrantly expressed in various hormone-responsive tumors, including prostate, breast, and ovarian carcinomas. Clone F1G4 provides strong and consistent cytoplasmic and membranous staining in formalin-fixed, paraffin-embedded tissues, making it a powerful tool in both diagnostic and research applications related to reproductive oncology and endocrinology.
Mouse
A synthetic peptide consisting of amino acids 1-29 (MANSASPEQNQHCSAINNSI PLMQGNLPY) from the N-terminus of the human GnRH receptor.
F1G4; same as GNRH03
IgG1, kappa
Human and Rat. Predicted to react with Pig and Rabbit. Others not known.
T47D cells. Pituitary gland, ovarian or breast cancers.
his antibody recognizes an epitope on the extracellular domain of the gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR).
Cytoplasmic