The h-Caldesmon Antibody (Mouse Monoclonal) from GeneBioSolution is a high-quality antibody validated for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues. h-Caldesmon is a cytoskeletal, actin-binding protein expressed in smooth muscle cells, playing a critical role in regulating contraction and maintaining cytoskeletal structure. This antibody provides sensitive and specific cytoplasmic staining of h-Caldesmon, with minimal background. It is widely used as a reliable marker of smooth muscle differentiation, helping pathologists distinguish leiomyosarcomas and other smooth muscle tumors from morphologically similar neoplasms. In diagnostic pathology, h-Caldesmon is often employed in an antibody panel alongside SMA, Desmin, and Calponin for accurate tumor classification. It is particularly valuable in differentiating leiomyosarcoma from gastrointestinal stromal tumors (GISTs), as h-Caldesmon is consistently expressed in smooth muscle tumors but absent or reduced in GISTs. Beyond diagnostic use, h-Caldesmon is also applied in research studies related to smooth muscle physiology, cytoskeletal dynamics, and cancer biology. All GeneBioSolution antibodies undergo rigorous validation and quality control, ensuring lot-to-lot consistency, high specificity, and reproducible IHC results on both manual and automated staining platforms. Clinical & Research Applications Diagnostic marker of smooth muscle differentiation Differentiation of leiomyosarcoma from GIST and other spindle cell tumors Used in antibody panels with SMA, Desmin, and Calponin for tumor classification Research on smooth muscle physiology and cytoskeletal regulation
For Research Use Only (RUO).
mouse
Highly specific for h-Caldesmon, a smooth muscle actin-binding protein. Distinguishes smooth muscle tumors (leiomyosarcoma, leiomyoma) from morphologically similar neoplasms such as GISTs and fibroblastic tumors. No significant cross-reactivity detected with non-smooth muscle tissues under tested IHC conditions
hHCD
IgG
Human, Mouse
Tissues: Uterine smooth muscle, leiomyosarcoma, and vascular smooth muscle. Expected Staining: Strong cytoplasmic positivity in smooth muscle cells and smooth muscle tumors.
Cytoplasmic staining pattern. Localized in actin-binding structures of smooth muscle cells
This antibody has been pre-titered and quality controlled to work on formalin-fixed paraffin- embedded as well as acetone fixed cryostat tissue sections.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
